Interference of potato virus Y transmission by aphids using small peptide inhibitors

Potato virus Y (PVY) is a major yield-limiting pathogen in global potato production,
primarily transmitted by aphid vectors in a non-persistent manner. Because multiple
aphid species can transmit PVY within seconds of probing, traditional insecticides are
largely ineffective at preventing in-season virus spread. To address this challenge, we
are developing synthetic peptides designed to competitively inhibit PVY binding to its
receptor in the aphid stylet, thereby blocking virus acquisition or delivery. As part of this
ongoing work, we are evaluating different methods for delivering these peptides to host
plants under field-relevant conditions. In parallel, we are characterizing the putative PVY
receptor across multiple aphid species known to transmit the virus, with the goal of
improving peptide targeting and broadening efficacy. This research aims to reduce
aphid-mediated PVY transmission and decrease reliance on environmentally harmful
insecticides. Because PVY also affects other solanaceous crops, the outcomes of this
study may offer protective benefits beyond potato, potentially supporting more
sustainable crop protection strategies across diverse agricultural systems.