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Section Symposium

Medical, Urban, and Veterinary Entomology

Legacy and Innovation: Collaborative Pathways in DoD Pest, Vector, and Invasive Species Research

Targeted indoor residual spray as a novel, effective approach for Aedes aegypti control in Iquitos, Peru

Sunday, November 9, 2025
2:45 PM - 3:00 PM Pacific
Location: Oregon Convention Center, B117-119, OCC
Oral Presentation
Current efforts to reduce the burden of Aedes-borne viruses (ABVs) are proving futile. A relatively new vector control alternative for Aedes aegypti is targeted indoor residual spray (TIRS) in which residual insecticide is applied to exposed interior surfaces where mosquitoes rest, thus maximizing exposure and taking less time than traditional IRS. This study aimed to assess the effectiveness of TIRS for the control of Ae. aegypti in the city of Iquitos, a dengue endemic region in the Peruvian Amazon. We evaluated the efficacy and duration of two residual formulations, organophospate pirimiphos-methyl (Actellic® 300 CS) and pyrrole Chlorfenapyr (Certero® 240 SC) on four types of wall surface (wood, brick, concrete and plywood) using WHO cone bioassays. The most effective product, pirimiphos-methyl, was used in a cluster randomized control trial (CRCT). Mortality across all wall surfaces in WHO cone tests was 93% (1 d) and 76% (30 d) for pirimiphos-methyl, and 6% (1 d) and 2% (30 d) for Chlorfenapyr. The CRCT trial showed an average adult Ae. aegypti reduction per household of 93% (74% - 99% range) in TIRS treated clusters compared to 12% in untreated control clusters. Adult Ae. aegypti per household decreased by 97% in treated houses. Furthermore, space spray interventions conducted at the same time due to a dengue outbreak in Iquitos demonstrated no measurable Ae. aegypti reduction. Our results underscore the operational value of TIRS in urban ABV prevention programs and DoD contingency operations highlighting the importance of maintaining high intervention coverage to maximize impacts.