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Section Symposium

Physiology, Biochemistry, and Toxicology

Medical, Urban, and Veterinary Entomology

Coping Under Stress: Adaptive Strategies to Toxins by Arthropods

The genetic architecture of Helicoverpa armigera's resistance to flubendiamide

Tuesday, November 11, 2025
9:34 AM - 9:46 AM Pacific
Location: Oregon Convention Center, F151, OCC
Oral Presentation
Insecticide resistance has a significant impact on food production, environmental sustainability,
and human health. Helicoverpa armigera (Lepidoptera: Noctuidae), a major crop pest, rapidly
develops insecticide resistance. A previous study showed that the flubendiamide resistance in
this H. armigera strain is not associated with mutations in the ryanodine channel gene or an
increase in enzymatic detoxification. Thus, we explored the genetic underpinnings of H.
armigera resistance to flubendiamide using high-resolution Genome-Wide Association Studies
(GWAS) and Quantitative Trait Loci (QTL) mapping. GWAS identified six loci, one on
chromosome 1, three on chromosome 2 and two on chromosome 13, that correlate with reduced
susceptibility to flubendiamide. Concurrent QTL mapping pinpointed a major effect QTL on
chromosome 2 associated with resistance traits. The locus identified on chromosome 2 by
GWAS and QTL mapping is promising for developing molecular markers to monitor
flubendiamide resistance. The identified candidate genes may be associated with maintaining
calcium homeostasis in the cell and insecticide detoxification by the ATP-binding cassette
(ABC) family genes. Our findings suggest an oligogenic architecture and a different
mechanism of H. armigera resistance to flubendiamide in Brazil. Furthermore, these results
contribute to the development of molecular markers for effective management of insecticide
resistance.