The growing threat of insecticide resistance in Aedes aegypti poses significant challenges to vector control programs, especially in regions where pyrethroids remain a primary intervention tool. Current resistance detection methods often require time-intensive bioassays or molecular diagnostics. In this study, we explore the application of Raman spectroscopy, a quicker high-throughput analytical approach for identifying resistance associated biochemical profiles in Aedes aegypti.
Using a portable Raman spectrometer, we analyzed spectral profiles of both susceptible and resistant mosquito strains. This proof-of-concept study is to demonstrate the potential of Raman spectroscopy as a rapid phenotyping tool for field and laboratory surveillance of resistance. With further development, this approach could support early detection of resistance hotspots and improve the responsiveness of integrated vector management strategies.
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